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DOLASTATIN 10

DOLASTATIN 10

CAS: 110417-88-4

Molecular Formula: C42H68N6O6S

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DOLASTATIN 10 - Names and Identifiers

Name DOLASTATIN 10
Synonyms Dolastain10
B720389K560
DOLASTATIN 10
dolastatin 10
Dolastatin 10 (NSC-376128)
From dolabella auricularia (sea hare)
L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl] amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-
L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl] amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]]-
(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide
CAS 110417-88-4

DOLASTATIN 10 - Physico-chemical Properties

Molecular FormulaC42H68N6O6S
Molar Mass785.09
Density1.116±0.06 g/cm3(Predicted)
Boling Point903.6±65.0 °C(Predicted)
pKa13.81±0.46(Predicted)
Storage Condition-20°C
In vitro study Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia . These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI 50 values of 10 −5 -10 −6 μg/mL (10 −2 -10 −3 nM) against a similar minipanel of human cell lines. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10.

DOLASTATIN 10 - Risk and Safety

UN IDs3172
Hazard Class6.1(b)
Packing GroupIII

DOLASTATIN 10 - Preparation solution concentration reference

 1mg5mg10mg
1 mM1.274 ml6.369 ml12.737 ml
5 mM0.255 ml1.274 ml2.547 ml
10 mM0.127 ml0.637 ml1.274 ml
5 mM0.025 ml0.127 ml0.255 ml
Last Update：2024-01-02 23:10:35
DOLASTATIN 10
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Featured ProductsSpot supply
Product Name: Dolastatin 10,DLS 10,NSC 376128 Visit Supplier Webpage Request for quotation
CAS: 110417-88-4
Tel: +86-18821248368
Email: Int06@meryer.com
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QQ: 495145328 Click to send a QQ message
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Product Name: Dolastatin 10 Request for quotation
CAS: 110417-88-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
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Email: product@acmec-e.com
Mobile: +86-18621343501
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: dolastatin 10 Visit Supplier Webpage Request for quotation
CAS: 110417-88-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
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